Five people have died and several buildings were destroyed in the old quarter of the Yemeni capital, Sana’a.
Witnesses have described the attack as an air strike.
Sana’a’s old city has been inhabited for more than 2,500 years and was a center for the propagation of Islam, boasting more than 100 mosques, 14 public baths and more than 6,000 houses built before the 11th century.
UNESCO calls it a jewel of Islamic culture and added the site to its world heritage list in 1986.
Residents said the blast was caused by an air strike by the Saudi-led coalition that launched a bombing campaign against Houthi rebels in late March.
If confirmed it would be the first in old Sana’a since the bombing began.
Medics and witnesses said a missile hit the Qassimi neighborhood without exploding, killing five residents and destroying three three-story houses.
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